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Grant Recipients

Research Grant Recipients

2011

Emory University to Dr. Tamara Caspary for research on Defining the role of ALR13B in medulloblastoma oncogenesis.

Renewal Grants:

John Hopkins University to Dr. Eric Raabe for a second year of funding for Using normal human neural system cells to model pediatric high-grade glioma.

Pittsburgh Medical Center to Dr. Ian Pollack for research on Genomic alterations in pediatric malignant gliomas.

 


2009

The University of Texas MD Anderson Cancer Center ($150,000 over two years) for Dimpy Koul, Ph.D., Department of Neuro-Oncology, Targeting the ependymoma with signaling inhibitors and rational combinations using synthetic lethality screen.

Children's Cancer Research Institute UTHSCSA ($150,000 over two years) for Luiz Penalva, Ph.D., Department of Cellular and Structural Biology, RNA aptamers against Musashi1, a novel strategy to treat pediatric brain tumors.


2008

Tumor Tissue Consortium Planning Grant – In a major effort to speed treatment and cures for pediatric brain tumors and cancer, the Children’s Brain Tumor Foundation launched the initial phase of a tissue bank consortium designed to jump-start meaningful analyses that could lead to treatment and cures for these types of cancer, where survival rates are unacceptably low and neurocognitive and other damage is posed by today’s treatment options. With support from the International Licensing Industry Merchandisers’ Association, CBTF is conducting a feasibility study with participation by leading pediatric institutions. Through the multi-institution research program, participating hospitals will agree to collect and analyze tissue samples and share data publicly. A standardized database will be used to collect and centrally record clinical data.


2007

St. Jude Children’s Research Hospital ($150,000 over two years) for Suzanne Baker, Ph.D., Department of Developmental Neurobiology, Molecular Genetics of Pediatric High-grade Glioma.

The University of Louisiana at Monroe ($150,000 over two years) for Karen Briski, Ph.D., Department of Pharmacology and Neuroanatomy, Novel Delivery Modes for Small Molecule Inhibitors of Medulloblastoma.

UCSF Pediatrics ($150,000 over two years) for Louis Chesler, M.D., Ph.D., Hematology-Oncology, The Role of MYCN in Medulloblastoma Tumor Progression and Efficacy of P13K Inhibitors.

University of Pittsburgh ($150,000 over two years) for Ian Pollack, M.D., Dept. of Neurosurgery, Children’s Hospital of Pittsburgh, Molecular Predictors of Prognosis for Childhood Oligodendrogliomas.

St. Jude Children’s Research Hospital ($150,000 over two years) for Martine Roussel, Ph.D., Department of Genetics and Tumor Cell Biology, Micro-RNAs in Cerebellar Development and Medulloblastoma.


2006

Children's Hospital Los Angeles (2006 LIMA International Award for Excellence in Pediatric Brain Tumor Research) for Anat Erdreich-Epstein, M.D., Ph.D., Assistant Professor of Pediatrics and Pathology, Molecular role of integrins in bone-marrow derived angiogenesis of pediatric brain tumors.

University of Medicine and Dentistry of New Jersey - The Robert Wood Johnson School of Medicine/The Cancer Institute of New Jersey (2006 Integra LifeSciences Award for Excellence in Pediatric Brain Tumor Research) for John Glod, M.D., Ph.D., Assistant Professor of Pediatrics, The Role of Monocytes in Brain Tumor Angiogenesis.

Memorial Sloan-Kettering Cancer Center (2006 Brain Tumor Foundation for Children Collaborative Grant) for Anna Marie Kenney, Ph.D., Assistant Professor of Cell Biology, mRNA Translation Machinery in Medulloblastoma.


2005

Johns Hopkins University School of Medicine (2005 House of Hope Grant) for Neil Watkins, M.D., Ph.D., Assistant Professor of Oncology at The Johns Hopkins University School of Medicine, A mouse model of HIC1gene silencing in medulloblastoma.

Hospital for Sick Children (2005 LIMA International Award for Excellence in Pediatric Brain Tumor Research) for Annie Huang, M.D., Ph.D., Neuro-oncologist, Assistant Professor, Genomic analyses of pediatric supratentorial primitive neuroectodermal tumors.

Washington University School of Medicine (2005 Andrew Hennessy Memorial Grant for Scientific Research,) for Joshua Rubin, M.D., Ph.D., Assistant Professor in Pediatrics, Molecular Mechanisms of CXCR4 Dependant Brain Tumor Growth.


2004

St. Jude Children's Research Hospital (2004 LIMA International Award for Excellence in Pediatric Brain Tumor Research, $150,000 over two years) for Tom Curran, Ph.D., Member, St. Jude Faculty; Chair, Developmental Neurobiology; Co-Leader, Neurobiology & Brain Tumor Program, Molecular Analyses of Atypical Teratoid/Rhabdoid CNS Tumors.

Baylor College of Medicine (2004 Nicholas Leone Memorial Grant for Scientific Research, $150,000 over two years) for Ching Lau, M.D., Ph.D., Associate Professor, Genomic Profiling of Intracranial Germ Cell Tumors.

Fred Hutchinson Cancer Research Center ($150,000 over two years) for Jim Olson, M.D., Ph.D., Associate Member, Necessity and Sufficiency of Nmyc in Sonic Hedgehog-Mediated Medulloblastoma Genesis.

University of Texas M.D. Anderson Cancer Center ($150,000 over two years) for Vidya Gopalakrishnan, Ph.D., Instructor, Molecular Genetics, Mechanism of REST/NRSF—Mediated Medulloblastoma Tumorigenesis.


2003

Princeton University (Nicholas Leone Memorial Grant for Scientific Research, $150,000 over two years) for Jonathan Eggenschwiler, Ph.D., Assistant Professor, The Role of Novel Hedgehog signaling antagonists in Medulloblastoma Tumorigenesis.

St. Jude Children's Research Hospital (2003 CBTF Inspiration Award for Pediatric Brain Tumor Research Grant, $150,000 over two years) for Martine F. Roussel, Ph.D., Genetics and Tumor Cell Biology, Role of Cyclin-dependent Kinase Inhibitory Proteins in Cerebellar Development and Tumorigenesis.

Dana-Farber Cancer Institute ($150,000 over two years) for Mark W Kieran, M.D., Ph.D., Director of Pediatric Neuro-Oncology, avb3-Receptor-based Novel Imaging in Orthotopic Models of CNS Malignancy after Biologic and Anti-angiogenic Therapy.

University of California ($150,000 over two years) for Daphne Haas-Kogan, M.D., Assistant Professor, Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Pediatric Gliomas.

Children's Hospital Boston ($150,000 over two years) for Scott L. Pomeroy, M.D., Ph.D., Associate Professor of Neurology, Wnt and TGFß in Medulloblastoma Oncogenesis.

University of Chicago ($150,000 over two years) for Manuel Utset, M.D., Ph.D., Assistant Professor, A Transgenic Mouse Model of Interferon-Gamma Induced Medulloblastoma.


2002

Columbia University (2002 Inspiration Award for Pediatric Brain Tumor Research Grant, $100,000 over two years) for Peter Canoll, M.D., Ph.D., Assistant Professor, The Role of Eph-Ephrin Interactions in Glioma Migration.

Duke University Medical Center ($100,000 over two years) for Robert Wechsler-Reya, Ph.D., Assistant Professor, Molecular Evolution of a Brain Tumor: Analysis of Pre-Tumor Cells in Murine Medulloblastoma.

Texas Children's Cancer Center ($100,000 over two years) for Michael Sheldon, Ph.D., Assistant Professor, Detection of Chromosomal Imbalances in Pediatric Ependymoma.

Johns Hopkins School of Medicine ($100,000 over two years) for Charles Eberhart, M.D., Ph.D., Instructor in Pathology, Analysis of Notch Signaling in Medulloblastomas.


2001

Temple University Center for Neurovirology and Cancer Biology (2001 Jean & Nicholas Leone Research Grant, $50,000) for Krzysztof Reiss, Ph.D., Assistant Professor, Targeting Insulin-like Growth Factor 1 Receptor (IGF-IR) - JCV T-Antigen Functional Interaction in Cerebellar Medulloblastoma.

Albert Einstein College of Medicine of Yeshiva University, Department of Molecular Genetics (2001 Sascha Feher Memorial Research Grant $100,000 over two years) for Ganjam V. Kalpana, Ph.D., Associate Professor, Gene Expression Profile Analysis to Study the Tumor Suppressor Function of INI1/hSNF5 in Atypical Teratoid and Rhabdoid Tumors.

Mayo Clinic and Foundation ($100,000 over two years) for Corey Raffel, M.D., Ph.D., Professor of Neurologic Surgery, Murine Modeling of Human Medulloblastoma.


2000

NYU School of Medicine, Skirball Institute ($100,000 over 2 years) for Gordon J. Fishell, Ph.D., The Role of Notch Signaling during Mammalian Neural Stem Cell Proliferation and Differentiation.

Children's Hospital of Philadelphia, ($100,000 over 2 years) for C. Damodara Reddy, IGF-I Receptor Targeted Therapy of Primitive Neuroectodermal Tumors.


1999

UMDNJ-New Jersey Medical School ($90,000 over two years) for Peter W. Carmel M.D., Vascular Ebdithelial Growth Factor Receptor (VEGF-R), Somatostatin Receptor (SSTR) and Epidermal Growth Factor Receptor (EGFR) Regulation in Neovascularization and Malignant Degeneration in Pediatric Brain Tumors.

New York University Medical Center ($90,000 over two years) for Elizabeth W. Newcomb, Ph.D., Role of MDM2 in TGF-B Growth Inhibition: Clinical Implications for Pediatric Astrocytomas.

John Hopkins University School of Medicine, ($90,000 over two years) for Greg L. Semenza,M.D., Ph.D., Role of Hypoxia-Inducible Factor 1 in Brain Tumor Progression.

State University of NY at Stony Brook, ($90,000 over two years), Marian J. Evinger, Ph.D. / Robert I. Parker, M.D. Establishing the Molecular Phenotype of Medulloblastomas.

Children's National Medical Center, ($77,000 over two years), Tobey John MacDonald, M.D., Role of Integrin Subunit Alpha (V) in Brain Invasion and Angiogensis.


1998

Children's Hospital of Philadelphia ($70,000 over two years) for Greta R. Bunin, Ph.D., Pesticides, Glutathione-S-Transferase, and Astrocytoma in Children.

UMDNJ/Robert Wood Johnson Medical School ($90,000 over two years) for Emanuel DiCicco-Bloom, M.D. Negative Regulation of Neural Precursor Proliferation.

Memorial Sloan-Kettering Cancer Center ($85,000) for David Lyden, M.D., Ph.D. Determining the Function of Specific Id Genes in Pediatric CNS Tumorigenesis and Angiogenesis.


1997

Brookhaven National Laboratory ($42,500) for F. Avraham Dilmanian, Ph.D. Unidirectional Microbeam Radiation Therapy of Children's Brain Tumors Using Synchrotron X Rays.

New York University Medical Center ($81,000 over two years) for Douglas C. Miller, M.D., Ph.D. Differentiation, Proliferative Activity and Prognosis in Pediatric Primitive Neuroectodermal Tumors of the Central Nervous System.

New York University Medical Center ($85,000 over 2 years) for Howard Weiner, M.D. The Role of DDR/Cak, a Novel Cell Adhesion Receptor Tyrosine Kinase, in Pediatric Brain Tumors and Brain Development.

Columbia Presbyterian Medical Center ($85,000 over two years) for Darrell Yamashiro, M.D., Ph.D. The Role of TRK Receptors in the Pathogenesis of Medulloblastoma.


1996

Montefiore Medical Center ($100,000 over 2 years) for Katherine Freeman, Ph.D. The Epidemiology of Family Centered Stress: Deriving a Model to Treat Families of Children with Brain and Spinal Cord Tumors.

Children's Hospital of Philadelphia ($99,000 over 2 years) for Patricia Molloy, M.D. Pilot Study of Evaluation and Treatment of Tumor-related Obesity in Pediatric Patients with Hypothalamic/Chiasmatic Gliomas and Craniopharyngiomas.

Memorial Sloan-Kettering Cancer Center ($54,117) for Jamie Ostroff, Ph.D. The Use of Multiple Family Discussion Groups to Promote the Psychosocial Adaptation of Adolescent Brain Tumor Patients.

Memorial Sloan-Kettering Cancer Center ($42,000 over 2 years) for Charles Sklar, M.D. Gonadal Function and Reproductive Potential in Young Adult Survivors of Childhood Brain Tumors.


1995

University of Medicine & Dentistry of NJ ($92,200) for Cory Abate-Shen, Ph.D. Role of hox transcriptional regulatory proteins in pediatric brain tumors.

New York University Medical Center ($100,000 over 2 years) for Yang Liu, Ph.D. T Cell Recruitment, Costimulation, and Immunity to Brain Tumors.

New York University Medical Center ($70,000 over 2 years) for Sharon Oberfield, M.D. Suppression of Puberty and Height S/P CNS RT for Childhood Cancer.

Long Island Jewish Medical Center ($96,800 over 2 years) for Eliot Rosen, M.D. The Role of Scatter Factor as a Brain Tumor Angiogen.

New York University Medical Center ($97,500 over 2 years) for David Zagzag, M.D. Function of Tenascin in Pediatric Brain Tumor Angiogenesis: Clinical Implications.


1994

New York University Medical Center ($50,000) for Martin Grumet, M.D. Analysis of RPTPB in Human Brain Tumors.

New York University Medical Center ($50,000) for Daniel Meruelo, M.D. Safer Targeted Gene Therapy Vectors for Brain Tumors.


1993

Montefiore Medical Center ($25,000) Margaret Bradley, M.D. for An investigation of Medulloblastoma In Vitro.

Memorial Sloan-Kettering Cancer Center ($20,000) for Jonathan Finlay, M.B., Ch.B. An International Collaborative Study of Primary Central Nervous System Germ Cell Tumors of Childhood and Adolescence.

New York University Medical Center, Thomas Finlay, Ph.D. ($77,500 over 2 years) and Rider University, Jonathan Yavelow, M.D. ($77,500 over 2 years) for the collaborative study on Relationships between Proteases and their Inhibitors, Growth Factors and their Receptors and Tumorigenic Potential.

Kaplan Comprehensive Cancer Center, NYU Medical Center ($50,000 over two years) for Angel Pellicer, Ph.D. Study of P53cell relating to pediatric brain tumors 1991 New York University Medical Center ($30,000) for Roberta Hayes, Ph.D. Study of Pediatric Interleukin-II/LAK Therapy.


1991

New York University Medical Center ($30,000) for Roberta Hayes, Ph.D. Study of Pediatric Interleukin-II/LAK Therapy.


1990-1994

New York University Medical Center, general support of the Pediatric Neuro-oncology Program upwards of $345,000

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