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The following was released in Australian ABC news:
By Jesse Dorsett
Posted Tue Feb 12, 2013 9:50am AEDT
Queenslandscientists say they have found a new way of treating aggressive brain tumours.
The Queensland Institute of Medical Research (QIMR) say scientists have found the protein EphA3 causes cancer to grow in about half of glioblastoma multiforme tumour cases.
QIMR spokesman Dr Bryan Day says it has been eradicated in mice in lab trials.
"We've found a receptor that is expressed on 50 per cent of the aggressive form of adult brain cancer," he said.
"This receptor appears to have a functional role in maintaining cells in a more tumorgenic state.
"We've been able to target these cells using a radio-labelled antibody therapy in mice."
The QIMR says it hopes human trials will take place within the next three years.
Here is the article abstract:
Significant endeavor has been applied to identify functional therapeutic targets in glioblastoma (GBM) to halt the growth of this aggressive cancer. We show that the receptor tyrosine kinase EphA3 is frequently overexpressed in GBM and, in particular, in the most aggressive mesenchymal subtype. Importantly, EphA3 is highly expressed on the tumor-initiating cell population in glioma and appears critically involved in maintaining tumor cells in a less differentiated state by modulating mitogen-activated protein kinase signaling. EphA3 knockdown or depletion of EphA3-positive tumor cells reduced tumorigenic potential to a degree comparable to treatment with a therapeutic radiolabelled EphA3-specific monoclonal antibody. These results identify EphA3 as a functional, targetable receptor in GBM.
The full article can be found in the journal Cancer Cell, Volume 23, Issue 2, pgs. 238-248.