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Opinions about the Children’s Brain Tumor Tissue Consortium

November 30, 2009

Opinions about the Children’s Brain Tumor Tissue Consortium from three leading non-affiliated researchers across the United States. 

I think this is an excellent proposal...very thorough, innovative, very detailed and crucial to the understanding of pediatric brain tumors, led by a team with an outstanding reputation and involving the best of basic, translational and clinical input.
 
The methods are very valid and doable. I wish they could expand to several other institutions as well. I have no concerns and am thrilled that these investigators have banded together to finally accomplish this long standing goal. I would definitely support funding without any reservations
 

 
The bottom line is that this would be a great resource.  Although other series of genomically profiled tumors have been published, clinical annotation is often lacking and full profiling, including SNP’s, mRNA and protein studies generally is lacking; thus a publically available database of this sort will clearly be used by the community.
 

 
Genomic profiling of pediatric cancers has lagged behind the adult tumors. To a very large extent, the lack of progress reflects a failure of the current pediatric tissue banking system. The current tissue banking system is not configured to collect viable brain tumor materials and does not provide detailed correlative clinical data.
 
The proposal is impeccably well prepared. The principal investigator is well qualified to lead the effort. He has picked superb collaborators and collaborating institutions to lay the foundation of CBTTC. The work proposed could have a profound impact on pediatric brain cancers by enabling a new generation of targeted therapeutics. I would recommend approval this proposal with an outstanding level of enthusiasm.  
 

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