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Pediatric brain tumor survivor health challenges

Monday, August 16, 2010
A large study focused on documenting the strength and fitness of childhood brain tumor survivors has found that many face health challenges as they age. The study led by St. Jude Children's Research Hospital investigators showed that although most participants were young adults in their 20s, many...

ASCO: Hedgehog Drug Stirs Hope for Some Pediatric Brain Tumors

Monday, June 14, 2010
CHICAGO -- Positive early phase results could put a novel inhibitor of "sonic hedgehog" signaling in line to be the first targeted agent in the most common type of childhood brain tumor. The 13 children with refractory medulloblastoma included in the proof-of-principle study tolerated...

Lack of Efficacy of Bevacizumab Plus Irinotecan in Children With Recurrent Malignant Glioma and Diffuse Brainstem Glioma: A Pediatric Brain Tumor Consortium Study

Monday, June 14, 2010
Sridharan Gururangan, Susan N. Chi, Tina Young Poussaint, Arzu Onar-Thomas, Richard J. Gilbertson, Sridhar Vajapeyam, Henry S. Friedman, Roger J. Packer, Brian N. Rood, James M. Boyett, Larry E. Kun From the Preston Robert Tisch Brain Tumor Center; Duke University Medical Center, Durham, NC; Dana-...

Integrated Molecular Genetic Profiling of Pediatric High-Grade Gliomas Reveals Key Differences With the Adult Disease

Monday, May 24, 2010
Barbara S. Paugh, Chunxu Qu, Chris Jones, Zhaoli Liu, Martyna Adamowicz-Brice, Junyuan Zhang, Dorine A. Bax, Beth Coyle, Jennifer Barrow, Darren Hargrave, James Lowe, Amar Gajjar, Wei Zhao, Alberto Broniscer, David W. Ellison, Richard G. Grundy, Suzanne J. Baker

Childhood Cancer: Progress, But Need for Targeted Therapies

Wednesday, April 21, 2010
By Katherine Hobson First, the good news: better treatments saved the lives of about 38,000 childhood cancer patients between 1975 and 2006, with overall survival rates now at about 80%, according to a report published online yesterday in the Journal of Clinical Oncology. Now, the bad: while...

Childhood Cancer Survivors At Higher Odds of Early Death

Tuesday, April 6, 2010
MONDAY, April 5 (HealthDay News) -- People who develop cancer at a young age require lifelong monitoring and are at an increased risk of early death, according to the results of two new studies. In one report, published in the April 6 issue of the Annals of Internal Medicine, researchers estimated...

Children With Cancer Often Unaware of Study Participation

Tuesday, March 30, 2010
MONDAY, March 29 (HealthDay News) -- Pediatric cancer patients often do not realize their treatment is part of a research study, do not have a good understanding of the research in which they are participating, and feel uninvolved in the decision-making process, according to a study published...

Congressman Sestak Leads Charge for Increased Funding for Pediatric Cancer

Friday, March 12, 2010
Today, Pediatric Cancer Caucus Chair Congressman Joe Sestak (PA-07), joined by 48 members of Congress, sent a letter urging the Appropriations Committee to include $30 million for pediatric cancer research in the FY 2011 Labor-Health and Human Services-Education Appropriations bill. Legislation...

Study Explores End-of-Life Experiences of Children With Brain Tumors

Tuesday, March 9, 2010
ScienceDaily (Mar. 1, 2010) — Parents and clinicians caring for children with brain tumors may experience significant challenges near the end of life due to the neurologic deterioration that often occurs in these patients. Shayna Zelcer, M.D., F.R.C.P.C., of Children's Hospital, London Health...

Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor {alpha} and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets

Tuesday, March 9, 2010
Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets Maryam Zarghooni, Ute Bartels, Eric Lee, Pawel Buczkowicz, Andrew Morrison, Annie Huang, Eric Bouffet, Cynthia...

Universal Poor Survival in Children With Medulloblastoma Harboring Somatic TP53 Mutations

Tuesday, March 9, 2010
 Uri Tabori, Berivan Baskin, Mary Shago, Noa Alon, Michael D. Taylor, Peter N. Ray, Eric Bouffet, David Malkin, Cynthia Hawkins From the Divisions of Haematology/Oncology, Molecular Genetics, Neurosurgery, and Pathology and The Labatt Brain Tumor Research Centre, The Hospital for Sick...

Notch-blocking drugs kill brain cancer stem cells, yet multiple therapies may be needed

Wednesday, March 3, 2010
Working with mice, Johns Hopkins scientists who tested drugs intended to halt growth of brain cancer stem cells - a small population of cells within tumors that perpetuate cancer growth - conclude that blocking these cells may be somewhat effective, but more than one targeted drug attack may be...

2010 Research Grants Announcement

Wednesday, February 24, 2010
Applications for Children's Brain Tumor Foundation 2010 researcher-initiated basic and translational research grants will be available online beginning March 1, 2010. 

Researchers Identify a Potential Therapeutic Target for Brain Cancer

Tuesday, February 23, 2010
Researchers Identify a Potential Therapeutic Target for Brain Cancer ScienceDaily (Feb. 23, 2010) — Researchers at the Cleveland Clinic report the identification of a protein that is highly expressed in a subgroup of glioblastoma brain tumor cells and show that depletion of this protein...

Tumor mechanism identified

Tuesday, February 23, 2010
Researchers from the Peninsula Medical School in Plymouth (UK), the Memorial Sloan-Kettering Cancer Center in New York, Cornell University in New York, Weil Medical College in New York and the Center for Neural Tumour Research in Los Angeles, have for the first time identified a key mechanism that...

Gene Mutation Linked to Poor Survival in Children with Medulloblastoma

Thursday, February 11, 2010
Results from a small, retrospective study suggest that a single genetic mutation may be linked to poor survival in children with medulloblastoma, the most common type of pediatric brain tumor. In the study, released online February 8 in the Journal of Clinical Oncology, no patient with...

UCLA researchers perform complete genomic sequencing of brain cancer cell line

Tuesday, February 9, 2010
Researchers at UCLA's Jonsson Comprehensive Cancer Center have performed the first complete genomic sequencing of a brain cancer cell line, an advance that could lead to personalized treatments based on the unique biological signature of an individual's cancer and that may unveil new molecular...

New therapies improving survival in patients with glioblastoma

Tuesday, February 9, 2010
Although gliomas and glioblastomas are not the most commonly occurring cancers — there are about 10,000 new cases in the United States each year — they are among the most deadly. The median survival of people diagnosed with these cancers is between 12 and 15 months.

The metabolic syndrome in cancer survivors

Friday, February 5, 2010
The metabolic syndrome, as a cluster of cardiovascular risk factors, may represent an important connection between cancer treatment and its common late effect of cardiovascular disease. Insight into the aetiology of the metabolic syndrome after cancer treatment might help to identify and treat...

Cancer, Autism Push By Obama to Spur New Medicines

Wednesday, February 3, 2010
By Pat Wechsler

St. Jude Children’s Research Hospital and Washington University Team to Unravel Genetic Basis of Childhood Cancers

Monday, February 1, 2010
Newswise — St. Jude Children’s Research Hospital and Washington University School of Medicine in St. Louis, today announced an unprecedented effort to identify the genetic changes that give rise to some of the world’s deadliest childhood cancers. The team has joined forces to...

Childhood Cancer Survivors Face Challenges at School

Friday, January 29, 2010
Survivors of childhood brain cancer or other central nervous system cancers, or leukemia, are less successful in school than their peers, a new study has found. British researchers examined data collected from more than 10,000 five-year survivors of all types of childhood cancer and compared it...

Study Aims to Help Minority Childhood Cancer Survivors Stay Healthy as Adults

Thursday, January 28, 2010
An estimated one in 640 adults have survived childhood cancer, but very little is known about the lifestyle and health behaviors of these survivors -- especially minority survivors -- as they grow older.

NIH Announces New Program to Develop Therapeutics for Rare and Neglected Diseases

Thursday, January 21, 2010
rarediseases.info.nih.gov/files/TRND%20Press%20Release.pdf

Brain Tumor Funders’ Collaborative Announces 11 New Grants

Wednesday, January 20, 2010
Funding by non-profit collaborative group will spur testing of non-invasive methods for monitoring brain tumor responses to new therapies ST. LOUIS, MO (January 20, 2010) – The Brain Tumor Funders’ Collaborative (BTFC) today announced the award of 11 one-year feasibility grants of $100...

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